In MCF-7, MCF-10, and MDA-MB-231 human breast cancer cells, LOX, but not COX, inhibitors block EGF/transforming growth factor α stimulation of 12-HODE, and 13-HODE production and cellular proliferation (Natajaran et al. 1997; Reddy et al. 1997). Here, LOX is linked to breast carcinoma.