TSPAN4 and systemic sclerosis: Since we have already shown that anti-UL94 peptide antibodies promote endothelial cell apoptosis following engagement of the NAG-2 molecule [11], we decided to analyze the gene expression profiles induced in endothelial cells by the anti-hCMV antibodies in order to identify clusters of genes known to be involved in the pathogenesis of vascular damage in SSc.