IL4R and asthma: However, patients who were carriers of both the T allele of -33C>TIL4 and the A allele of IL4RA had an increased risk of asthma [Fisher's p value = 0.017, Monte Carlo p value (after 104 simulations = 0.012, odds ratio, 2.58; 95 % CI, 1.18–5.66].