TYR and vitiligo: Though these autoantibodies have been shown to be able to damage pigment cells both in vitro and in vivo, more recently it has been reported that specific autoantibodies for tyrosinase are present at low frequency in the sera of vitiligo patients, and that such autoantibody titers may be found both in vitiligo-like depigmentation (melanoma-associated depigmentation) and in healthy controls [3].