ANK2 and cardiac rhythm disease: Moreover, ankyrin-B+/− mice have a related cardiac arrhythmia, and ankyrin-B+/− cardiomyocytes are also deficient in the complex, while the expression and subcellular localization of other cardiac ion channels and transporters (e.g., Nav channels, which associate with a second ankyrin gene product, ankyrin-G) remain normal [15,18,34].