hSecurin+/+ cells and chromosomally stable hSecurin−/− cells in various stages of mitosis were stained with the CREST (calcinosis-Raynaud's phenomenon-esophageal dismobility-sclerodactyly-telangiectasia syndrome of scleroderma) antibody, which recognizes kinetochore proteins (Figure 4). The gene discussed is SS18L1; the disease is scleroderma.