Although Stat3 (S727) remains correlate well with kinases in this cascade including EGFR, PDK-1, AKT, mTOR, p70S6K and S6 (P<0.05 in Table 1), phosphorylated Stat3 (Y705) did not correlate with PDK-1 phosphorylation in this study (P>0.05; Table 2), despite it is associated with invasive breast carcinoma (P<0.05; Table 2). The gene discussed is PDK1; the disease is invasive breast carcinoma.