Whether a low level of secretin may contribute to the high prevalence of acid reflux needs further investigations, but our report confirms the suggestion of Horvath & Perman [31] that gastrointestinal abnormalities may contribute to some of the behavioral problems, and the presence of esophagitis correlates well with the reported symptoms and may in part explain the sudden irritability, crying behavior and diet restriction as shown in our first case. Here, SCT is linked to esophagitis.