At 112 days, the relative lung and spleen weights as indicator of inflammation and pathology were significantly increased in mem-TNF mice (Fig. 4B) and viable mycobacteria in lungs were almost two logs higher (Fig. 4C), reaching 107 CFU, a bacterial load still much lower than that observed in moribund TNF-KO mice after 30 days of infection (Fig. 2D). Here, TNF is linked to infection.