Furthermore, the recent findings show that the homozygous GSTP1 Ile105Val genetype was significantly under-represented in NSCLC compared with controls especially in females, and neither GSTM1 nor MPO genotypes affected the overall risk of NSCLC, and the MPO and CYP1A1 risk genotypes interacted to increase overall risk of NSCLC[26]. The gene discussed is CYP1A1; the disease is non-small cell lung carcinoma.