To further investigate whether differences found in protein levels of CYPs between normal tissue of patients with adenoma and disease-free controls are related to the mRNA expression of CYPs, protein levels of CYP2C8, CYP3A4, and CYP3A5 of subjects with detectable mRNA expression were compared to those with undetectable mRNA expression of the respective CYP. This evidence concerns the gene CYP2C8 and adenoma.