Using Luzp2 as an example, we demonstrate that analysis of phylogenetically conserved sequences and consideration of synteny allows the fine mapping of a putative neuronal enhancer element(s), while a similar model likely also applies for Chrna7. In human, CHRNA7 is of significant interest as a schizophrenia candidate gene with both genetic and functional support [46-48]. The gene discussed is LUZP2; the disease is schizophrenia.