Based on these results we suggested the use, in patients with hyperparathyroidism secondary to uremia, of non-1α-hydroxylated vitamin D analogues that may become hydroxylated locally in parathyroid cells to an active vitamin D receptor (VDR) binding compound with parathyroid hormone (PTH)suppressive and antiproliferative activities [27]. Here, VDR is linked to hyperparathyroidism.