BCL2 and Splenomegaly: Although AS Bcl-2 ODNs induced splenomegaly and increased serum IL-12 levels in the present experiment, suggesting an immunostimulatory effect of AS Bcl-2, the antitumor effect of AS Bcl-2 ODNs seemed to result from downregulation of Bcl-2, independently of CpG-mediated immune stimulation.