Individuals who carried genotypes predicting both high-activity SULT1A1*1/*1 and high-activity UGT1A1*1/*1, UGT1A1*1/*33 and UGT1A1*33/*33 presented with low tumor grade (grade 1) (OR = 2.56, CI = 1.04–6.25, P = 0.05; Table 3). The gene discussed is SULT1A1; the disease is neoplasm.