Along this line, several preclinical observations have shown that NF-κB plays a role in prostate cancer growth, survival, angiogenesis and metastatic progression (Muenchen et al, 2000; Yu et al, 2000; Catz and Johnson, 2001; Huang et al, 2001; Gasparian et al, 2002; Gunawardena et al, 2002; Gupta et al, 2002; Suh et al, 2002; Zerbini et al, 2003; Suh and Rabson, 2004). The gene discussed is NFKB1; the disease is prostate cancer.