RHOA and Familial prostate cancer: Moreover, in prostate cancer cells, constitutive activation of NF-κB has been associated to the activation of signalling transduction pathways involving tyrosine kinases and, more specifically, molecules such as Rho-A, Ki-Ras or PTEN/Akt (Gasparian et al, 2002; Li and Sarkar, 2002; Kim et al, 2002; Mayo et al, 2002; Hodge et al, 2003).