Our results show that PaTrin-2 is also a potent inactivator of MGMT in MCF-7 cells both in culture and in xenografts in vivo. Tumour MGMT depletion by PaTrin-2 was as extensive as was reported with O6-BeG in other tumour types (see Dolan and Pegg, 1997). Here, MGMT is linked to neoplasm.