The Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) trial [23] was a phase III study designed to evaluate drotrecogin alfa (activated) for the treatment of patients with severe sepsis at high risk for death (e.g. as determined by an Acute Physiology and Chronic Health Evaluation II score ≥25 and/or two or more organ dysfunctions). This evidence concerns the gene PROC and Sepsis.