In synovial tissue from patients with RA, p65 and p50 have been shown to be present in the nuclei of macrophage-like synoviocytes, fibroblast-like synoviocytes (FLS), and vascular endothelial cells, and probably play a pivotal role in the pathogenesis of RA [4-7]. This evidence concerns the gene NFKB1 and rheumatoid arthritis.