RAL reduction of u-PA-dependent proliferation was similar to the inhibition caused by the antagonist antibodies (p < 0.001 in normal and RA synoviocytes) (Fig. 2b) and was not increased by co-treatment with them, indicating a common target for RAL and anti u-PA/u-PAR antibodies (data not shown). Here, RALA is linked to rheumatoid arthritis.