Along with the approximate 15-fold increase in the frequency of apoptotic cells observed in the RA synovium three days after after Ad-FasL injection (Fig. 4) the number of both synoviocytes and mononuclear cells was greatly decreased in RA synovium after two months of treatment with repeated FasL gene transfers (Fig. 5d) compared with Ad-LacZ treated RA synovium (Fig. 5c). The gene discussed is FASLG; the disease is rheumatoid arthritis.