Finally, in order to identify the relationship between FCGR3A-158V allele and anti-GPI antibodies more clearly, we focused on individuals who were homozygous for the high affinity FCGR3A-158V/V genotype (14 RA patients and eight healthy individuals) and compared their anti-GPI antibody titres. This evidence concerns the gene FCGR3A and rheumatoid arthritis.