To examine the involvement of VEGFR-2 signaling in the stimulation of ADAM15 expression with TNF-α and VEGF165, RA SFs were incubated with SU1498, a selective VEGFR-2 tyrosine kinase inhibitor, prior to the stimulation with VEGF165 and ADAM15 mRNA expression was examined. The gene discussed is ADAM15; the disease is rheumatoid arthritis.