The iMycEμ mice provide a model system for the study of the molecular and oncogenic consequences of the human MYC- and mouse Myc-deregulating chromosomal t(8;14)(q24;q32) and T(12;15) translocations that are widely accepted as the crucial initiating oncogenic events in the great majority of human Burkitt lymphomas (BL) and mouse plasmacytomas, respectively [2]. Here, MYC is linked to plasmacytoma.