The definitive proof for a causal connection between nuclear architecture and human aging came with a stunning discovery in the summer of 2003, when the groups of Francis Collins and Nicolas Levy identified mutations in the lamin A gene (LMNA) as the genetic cause of the segmental premature aging disease Hutchinson-Gilford progeria syndrome (HGPS) [5,6] (Box 1). The gene discussed is LMNA; the disease is Hutchinson-Gilford progeria syndrome.