In stark contrast, all primary B cells infected with the EBNA2− mutant 2491, which expressed BALF1 and BHRF1 transcripts immediately after infection (see Figure 2C), were alive on day 3 p.i., about 15% survived until day 5, and a few percent of the cells were GFP+/Annexin-V−/PI− 8 d p.i. (Figure 4D and 4E). The gene discussed is ANXA5; the disease is infection.