The hypothesis that the presence of the polymorphism of ADRB3 alone does not affect the risk of obesity is supported by the finding that when the subjects were classified into two groups according to presence of the polymorphism, no significant difference in waist circumference or BMI was seen between the subjects with and without the polymorphism (84.1±9.19 vs 83.5±9.57, and 23.4±3.20 vs 23.2±3.47, respectively) (Table 1). This evidence concerns the gene ADRB3 and obesity due to melanocortin 4 receptor deficiency.