However, the findings that no significant difference in waist circumference or BMI was seen between the subjects with and without the polymorphism indicate that the effect of the polymorphism in the development of obesity is rather small and that it may be difficult to carry out tailor-made prevention or treatment of obesity based on genotyping of the Trp64Arg polymorphism of ADRB3 alone. This evidence concerns the gene ADRB3 and obesity due to melanocortin 4 receptor deficiency.