The results of the multiple logistic regression analysis on obesity (defined as waist circumference 85+ cm17) in the 4th quartile (total: 74, without polymorphism: 48, with polymorphism: 26) are shown in Table 5, in which the presence of ADRB3 polymorphism, smoking, age and physical activity were independent variables. This evidence concerns the gene ADRB3 and obesity due to melanocortin 4 receptor deficiency.