A study comparing BMI, waist circumference, and waist-hip ratio (WHR) in regard to their respective associations with accumulation of abdominal visceral adipose tissue showed that the highest significant positive correlation was between waist circumference and abdominal visceral adipose tissue area measured by computed tomography in both men and women (r=0.77 and 0.87, respectively).25 When obesity was defined according to waist circumference not BMI in the present study, the interaction between the polymorphism of ADRB3 and high energy intake was found to increase the risk of obesity. This evidence concerns the gene ADRB3 and obesity due to melanocortin 4 receptor deficiency.