IR-induced damage is ameliorated by spin traps [2], inhibition of inducible nitric oxide synthase [3], lecithinized superoxide dismutase (SOD) [3], ebselen, a ONOO- scavenger [3], inhibitors of calpain activation [4], SOD and catalase (CAT) mimetic [6], antioxidants [7,8], or in the other circumstances such as hypothyroidism [9]. This evidence concerns the gene SOD1 and hypothyroidism.