This may be relevant to the protective effect of hypothyroidism in ischemia and reperfusion since it has been recognized that mitochondria play a key role in cell-death pathways by activating mitochondrial permeability transition pore and causing the release of cytochrome C and proapoptotic factors, as well as Ca2+ overload that promotes non-selective permeability of the inner membrane. Here, CYCS is linked to hypothyroidism.