GRP78 and GRP94 were over-expressed in the same tumours that showed over-expression of ATF6. GRP78 was over-expressed 8-fold in MS8x, 5-fold in LS21 and 3-fold in LS3x, whereas GRP94 was over-expressed 3-fold in LS3x and 2-fold in LS21 and MS8x. This evidence concerns the gene ATF6 and neoplasm.