Recently, the ras effectors/tumour suppressors RASSF1 and NORE1 were found to be inactivated by promoter hypermethylation in a variety of human tumours (Vavvas et al, 1998; Dammann et al, 2000; Pfeifer et al, 2002; Hesson et al, 2003; Vos et al, 2003b). Here, RASSF1 is linked to neoplasm.