They identified the RASSF2 promoter region and showed that absence of RASSF2 transcription was caused by DNA methylation, not by alteration of transcription factors, and also showed histone acetylation at the 5′ region of RASSF2 in colorectal cancer cell lines with DNA methylation (Akino et al, 2005). This evidence concerns the gene RASSF2 and colorectal cancer.