SFTPD and infection: However, by 48 hrs post-infection, there was a significant decrease in SP-D-/- mouse lung neutrophil numbers (P < 0.05 compared to 24 hrs) whereas the number of neutrophils in SP-D+/+ lungs at 48 hrs further increased as compared to 24 hrs and as compared to SP-D-/- mice at equivalent timepoint (P < 0.05, Table-1A).