For example, the lactase gene (LCT, associated with lactose tolerance) has one of the highest relative extended haplotype homozygosity (rEHH [25]) scores in the CEU population, as does the beta-globin gene (HBB, associated with protection against Plasmodium falciparum malaria) in the YRI population. This evidence concerns the gene HBB and Plasmodium falciparum malaria.