ROBO1 and dyslexia: The authors show that an axon guidance receptor gene, ROBO1, is disrupted by a chromosomal translocation in one dyslexic individual; furthermore, this study shows that the expression of ROBO1 is reduced on chromosomes from dyslexics in a large pedigree in which dyslexia has been linked to DYX5. ROBO1 has a role in regulating axon crossing across the midline between brain hemispheres and guidance of neuronal dendrites.