TP53 and squamous cell carcinoma: Finally, Ito et al. [37] studied the expression of HSP27, -60, -70 and -90 in 24 squamous cell carcinomas of the tongue using immunohistochemistry, finding that HSP immunoexpression might change during tumorigenesis, but there was no correlation between HSP staining and survival period, clinical stage, lymph node metastasis, histological grade or p53 immunostaining.