TP53 and metastatic malignant neoplasm in the lymph nodes: Finally, Ito et al. [37] studied the expression of HSP27, -60, -70 and -90 in 24 squamous cell carcinomas of the tongue using immunohistochemistry, finding that HSP immunoexpression might change during tumorigenesis, but there was no correlation between HSP staining and survival period, clinical stage, lymph node metastasis, histological grade or p53 immunostaining.