PRKDC and cancer: DNA-PK inhibitors, such as LY294002 and wortmannin, and also antisense oligonucleotides have been shown to induce radiosensitisation in a variety of cancer cell lines (Rosenzweig et al, 1997; Chernikova et al, 1999; Chiosis et al, 2001; Kim et al, 2002; Sak et al, 2002).