HSP70 mRNA increased early upon infection with a high vaccinia virus dose, and clear decrease was found fairly late, at 96 hours p.i. The transcript increase after low infectious dose was slowly reaching the maximum at 48 h p.i. The kinetics of HSP90 mRNA increase upon high vaccinia virus dose was similar to that of HSP70 mRNA, however its level decreased earlier than the levels of HSP70 transcript, as this was observed already at 72 hours p.i. At MOI 1, HSP90 mRNA increase was slow, similar to the increase of HSP70 mRNA. Here, HSP90AA1 is linked to infection.