EGFR amplification and EGFRvIII have been shown to increase glioma proliferation and invasion in vitro [8,9]; therefore logically EGFR and/or EGFRvIII expression could exhibit a proclivity towards the development of multifocal disease, gliomatosis cerebri or ependymal seeding. The gene discussed is EGFR; the disease is central nervous system cancer.