C-kit is one of these PTK, which is expressed in a wide variety of human malignancies [16] including chronic and acute myelogenous leukemia [6], GIST [7], mastocytosis [17], small cell lung carcinoma [18], chromophobe renal cell carcinoma [19], cutaneous [20] and UM [16]. Here, KIT is linked to acute myeloid leukemia.