Using a microarray strategy, we recently identified DRM/Gremlin as a gene that was differentially expressed in a non-small-cell lung carcinoma (NSCLC) cell line after treatment with a demethylating agent (5-aza-2′-deoxycytidine (5-Aza-CdR)). This evidence concerns the gene GREM1 and non-small cell lung carcinoma.