Recently, Chen et al demonstrated that overexpression of Drm in the tumour-derived cell lines Daoy (primitive neuroectodermal, HTB186) and Saos-2 (osteoblastic, HTB-85) transcriptionally activates p21Cip1 via a novel mechanism, independent of p53 and both p38 and p42/44 MAP kinases, and inhibits neoplastic transformation (Chen et al, 2002). The gene discussed is GREM1; the disease is neoplasm.