NOS1AP and schizophrenia: In this month's PLoS Medicine, Linda Brzustowicz and colleagues present the results of their study of one potential schizophrenia susceptibility gene, CAPON (carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase), using postmortem tissue samples of the dorsolateral prefrontal cortex, a pathological “hotspot” identified in studies of schizophrenia [2].