The association of intermediate filaments with desmosomal junctions in meningiomas, arachnoid membrane, and arachnoid granulations was first reported by Kartenbeck et al. and Schwecheimer et al. [10,14], who demonstrated that desmosomal plaques anchored vimentin filaments, while cytokeratin immunoreactivity within these tissues was not found. The gene discussed is VIM; the disease is meningioma.