Both AEI and AI were measured in a series of informative patients using mRNA-encoded cSNPs for SERPINB5 (encoding maspin), TERT (encoding a telomerase subunit) and PRAME (encoding a tumour antigen of unknown function with a highly restricted normal tissue expression pattern (Heighway et al, 2002). The gene discussed is SERPINB5; the disease is neoplasm.