These IMiDs can also interfere with myeloma cell–bone marrow stromal cell interactions by affecting adhesion molecule expression, which might be crucial for MM cell growth and survival, and prevent the upregulation of IL-6 and vascular endothelial growth factor (VEGF), which is involved in angiogenesis (Gupta et al, 2001). This evidence concerns the gene VEGFA and Miyoshi myopathy.