GSTM1 and metastatic neoplasm: • Age equal or greater than 18 years• Primary inoperable locally advanced pancreatic adenocarcinoma• No evidence of metastatic disease.• Hb >10.0 g/%, WBC >3,000 cells/mm3, platelets >100,000 cells/mm3.• Performance status: Karnofsky ≥70.• No acute infections at the time of therapy initiation.• Patient must be able to give informed consent• Patient has given informed consent