To evaluate whether FAK and β1 integrin affect IL-1α-induced activation of Ras and ERK, pancreatic cancer cells were transfected with FAK siRNA or treated with anti-β1 integrin antibody for 30 min before being exposed to rIL-1α for 30 min on Coll IV. The gene discussed is PTK2; the disease is familial pancreatic carcinoma.