IL1A and familial pancreatic carcinoma: We also previously reported that the enhancement of α6β1-integrin expression by IL-1α acting through IL-1RI plays a critical role in adhesive and invasive behaviors in pancreatic cancer, and proved that the strong expression of the α6 integrin subunit in pancreatic cancer tissue significantly correlated with the poor prognosis and the presence of hepatic metastases in pancreatic cancer patients [15,16].