However, even though concomitant presence of TNFRII 196R allele and at least one HLA-DR1/DR4 allele was also found to be associated with RA diagnosis (P = 0.012), their combination did not improve upon the diagnostic accuracy of the TNFRII 196R allele alone. The gene discussed is TNFRSF1B; the disease is rheumatoid arthritis.