Taking those data into account, the aim of this study was to assess the contribution of the TNFRII 196R allele, alone or in combination with HLA-DR1/DR4 alleles, in predicting RA diagnosis and prognosis in a community-based cohort of patients with very early arthritis (VErA study [6]). The gene discussed is TNFRSF1B; the disease is rheumatoid arthritis.