TNFRSF1B and rheumatoid arthritis: Recently, Till and coworkers [27], using transfected HeLa cell populations and immortalized fibroblasts from tnfr1-/-/tnfr2-/- double knockout mice, reported an altered induction of apoptosis and nuclear factor-κB pathway in the TNFRII 196R allele transfected cells, which could also serve as an explanation for the association of this allele with increased susceptibility to RA.