RELA and Familial prostate cancer: More recently, constitutive activation of NF-κB (RelA/p50) has been detected in androgen-independent prostate cancer cell lines as well as in prostate cancer tissues (Chen and Sawyers, 2002; Gasparian et al, 2002; Suh et al, 2002; Ayala et al, 2004; Ross et al, 2004; Shukla et al, 2004; Sweeney et al, 2004) and appears to promote cell growth, survival, and metastasis (Huang et al, 2001; Hodge et al, 2003; Levine et al, 2003; Ling et al, 2003).