VEGFA and neoplasm: When different isoforms of VEGF were transfected into the VEGF-null cells in isolation and the transfected cells were implanted into nude mice, it was found that VEGF165 was the most prominent isoform that can fully rescue expansion of the angiogenesis-deficient tumour, while VEGF121 and VEGF189 only partially or failed completely to rescue tumour growth, respectively [23].