Although colorectal cancer patients with overexpression of VEGF 23 kDa, which is believed to be VEGF165 (one of a secretable form of VEGF) in tumour tissues, possessed higher levels of circulating VEGF in serum (1190 ± 752 pg/ml) than those possessing undetectable level of VEGF165 (875 ± 330 pg/ml), it was not statistically significant (p = 0.207, Mann-Whitney test). The gene discussed is VEGFA; the disease is colorectal cancer.