Targeting Bax and Bak may be a common strategy for many viruses, since Bax and Bak are required for apoptosis during adenovirus infection, and the adenovirus v-Bcl-2 E1B 19K targets Bak and Bax for antiapoptotic function in cultured cells [7,72,73]. Here, BAK1 is linked to adenoviridae infectious disease.