In clinicopathological studies, a positive correlation between VEGF-C levels in primary breast carcinomas and lymph node metastases was observed only once (Kurebayashi et al, 1999; Gunningham et al, 2000; Kinoshita et al, 2001; Koyama et al, 2003). The gene discussed is VEGFC; the disease is metastatic malignant neoplasm in the lymph nodes.